No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model

INTRODUCTION: Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large-scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting. The present exploratory study is designed to determine the...

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Published in:Alzheimers Dement (N Y)
Main Authors: Baakman, Anne Catrien, Alvarez-Jimenez, Ricardo, Loewen, Gordon, de Kam, Marieke L., Broekhuizen, Karen, Hilt, Dana C., Groeneveld, Geert Jan
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446049/
https://ncbi.nlm.nih.gov/pubmed/30984817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2019.02.002
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