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Acute inhibition of heterotrimeric kinesin-2 function reveals mechanisms of intraflagellar transport in mammalian cilia

The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric KIF3A/KIF3B/KAP kinesin-2 motor prevents ciliogenesis in mammalian cells and has hindered an understanding of how kine...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Engelke, Martin F., Waas, Bridget, Kearns, Sarah E., Suber, Ayana, Boss, Allison, Allen, Benjamin L., Verhey, Kristen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445692/
https://ncbi.nlm.nih.gov/pubmed/30905605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.02.043
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