Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

During development of pancreatic cancer, alternatively-activated macrophages contribute to fibrogenesis, pancreatic intraepithelial neoplasia (PanIN) lesion growth, and generation of an immunosuppressive environment. Here we show that the immunomodulatory agent pomalidomide depletes pancreatic lesio...

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Publicat a:Cancer Res
Autors principals: Bastea, Ligia I., Liou, Geou-Yarh, Pandey, Veethika, Fleming, Alicia K., von Roemeling, Christina A., Doeppler, Heike, Li, Zhimin, Qiu, Yushi, Edenfield, Brandy, Copland, John A., Tun, Han W., Storz, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445670/
https://ncbi.nlm.nih.gov/pubmed/30696657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1153
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