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A single molecular distance predicts agonist binding energy in nicotinic receptors
Agonists turn on receptors because they bind more strongly to active (R*) versus resting (R) conformations of their target sites. Here, to explore how agonists activate neuromuscular acetylcholine receptors, we built homology models of R and R* neurotransmitter binding sites, docked ligands to those...
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| Udgivet i: | J Gen Physiol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445573/ https://ncbi.nlm.nih.gov/pubmed/30635370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812212 |
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