Abnormal islet sphingolipid metabolism in type 1 diabetes

AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of h...

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Pubblicato in:Diabetologia
Autori principali: Holm, Laurits J., Krogvold, Lars, Hasselby, Jane P., Kaur, Simranjeet, Claessens, Laura A., Russell, Mark A., Mathews, Clayton E., Hanssen, Kristian F., Morgan, Noel G., Koeleman, Bobby P. C., Roep, Bart O., Gerling, Ivan C., Pociot, Flemming, Dahl-Jørgensen, Knut, Buschard, Karsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445476/
https://ncbi.nlm.nih.gov/pubmed/29671030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4614-2
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