Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following spinal cord i...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Myers, Scott A., Gobejishvili, Leila, Ohri, Sujata Saraswat, Wilson, C. Garrett, Andres, Kariena R., Riegler, Amberly S., Donde, Hridgandh, Joshi-Barve, Swati, Barve, Shirish, Whittemore, Scott R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445388/
https://ncbi.nlm.nih.gov/pubmed/30557659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.12.008
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