Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

We discovered novel and selective sulfonamides/amides acting as inhibitors of the α-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA). This Gram-negative bacterium is the causative agent of cholera and colonises the upper small intestine where sodium bicarbona...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Enzyme Inhib Med Chem
Egile Nagusiak: De Vita, Daniela, Angeli, Andrea, Pandolfi, Fabiana, Bortolami, Martina, Costi, Roberta, Di Santo, Roberto, Suffredini, Elisabetta, Ceruso, Mariangela, Del Prete, Sonia, Capasso, Clemente, Scipione, Luigi, Supuran, Claudiu T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2017
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445327/
https://ncbi.nlm.nih.gov/pubmed/28569564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1327522
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