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Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

Inhibition of the β-carbonic anhydrase (CA, EC 4.2.1.1) from pathogenic Candida glabrata (CgNce103) by 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazones] 4a–m was investigated. All the compounds were found to be potent inhibitors of CgNce103, with inhibition constants in the range of 6....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Enzyme Inhib Med Chem
Main Authors: Akdemir, Atilla, Angeli, Andrea, Göktaş, Füsun, Eraslan Elma, Pınar, Karalı, Nilgün, Supuran, Claudiu T.
פורמט: Artigo
שפה:Inglês
יצא לאור: Taylor & Francis 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366411/
https://ncbi.nlm.nih.gov/pubmed/30724625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1564045
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