Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

A small collection of 26 structurally novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group, were synthesised and tested in enzyme inhibition assays against the tumour-associated hCA IX enzyme. Inhibition constants in the lower micromolar region (K(I) <...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Güzel-Akdemir, Özlen, Angeli, Andrea, Demir, Kübra, Supuran, Claudiu T., Akdemir, Atilla
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161604/
https://ncbi.nlm.nih.gov/pubmed/30249139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1499628
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