Pyridinium Derivatives of 3-Aminobenzenesulfonamide are Nanomolar-potent Inhibitors of Tumor-expressed Carbonic Anhydrase Isozymes CA IX and CA XII

Building on the conclusions of previous inhibition studies with pyridinium-benzenesulfonamides from our team and on the X-ray crystal structure on the lead compound identified, a series of 24 pyridinium derivatives of 3-aminobenzenesulfonamide was synthesized and investigated for carbonic anhydrase...

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Detalhes bibliográficos
Publicado no:Bioorg Chem
Main Authors: Akocak, Suleyman, Güzel-Akdemir, Özlen, Kishore Kumar Sanku, Rajesh, Russom, Samson S., Iorga, Bogdan, Supuran, Claudiu T., Ilies, Marc A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846937/
https://ncbi.nlm.nih.gov/pubmed/32891000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104204
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