Synthetic ligands for PreQ(1) riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

Riboswitches are naturally occurring RNA aptamers that regulate gene expression by binding to specific small molecules. Riboswitches control the expression of essential bacterial genes and are important models for RNA-small molecule recognition. Here, we report the discovery of a class of synthetic...

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Publicado no:Nat Commun
Main Authors: Connelly, Colleen M., Numata, Tomoyuki, Boer, Robert E., Moon, Michelle H., Sinniah, Ranu S., Barchi, Joseph J., Ferré-D’Amaré, Adrian R., Schneekloth, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445138/
https://ncbi.nlm.nih.gov/pubmed/30940810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09493-3
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