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WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kaiser, Karol, Gyllborg, Daniel, Procházka, Jan, Salašová, Alena, Kompaníková, Petra, Molina, Francisco Lamus, Laguna-Goya, Rocio, Radaszkiewicz, Tomasz, Harnoš, Jakub, Procházková, Michaela, Potěšil, David, Barker, Roger A., Casado, Ángel Gato, Zdráhal, Zbyněk, Sedláček, Radislav, Arenas, Ernest, Villaescusa, J. Carlos, Bryja, Vítězslav
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445127/
https://ncbi.nlm.nih.gov/pubmed/30940800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09298-4
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