Identification of Allosteric Inhibitors against Active Caspase-6

Caspase-6 is a cysteine protease that plays essential roles in programmed cell death, axonal degeneration, and development. The excess neuronal activity of Caspase-6 is associated with Alzheimer disease neuropathology and age-dependent cognitive impairment. Caspase-6 inhibition is a promising strate...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Tubeleviciute-Aydin, Agne, Beautrait, Alexandre, Lynham, Jeffrey, Sharma, Gyanesh, Gorelik, Alexei, Deny, Ludovic J., Soya, Naoto, Lukacs, Gergely L., Nagar, Bhushan, Marinier, Anne, LeBlanc, Andrea C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445123/
https://ncbi.nlm.nih.gov/pubmed/30940883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41930-7
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