Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b

Body and organ size regulation in mammals involves multiple signaling pathways and remains largely enigmatic. Here, we report that Pum1 and Pum2, which encode highly conserved PUF RNA-binding proteins, regulate mouse body and organ size by post-transcriptional repression of the cell cycle inhibitor...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lin, Kaibo, Qiang, Wenan, Zhu, Mengyi, Ding, Yan, Shi, Qinghua, Chen, Xia, Zsiros, Emese, Wang, Kun, Yang, Xiaodi, Kurita, Takeshi, Xu, Eugene Yujun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444939/
https://ncbi.nlm.nih.gov/pubmed/30811992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.111
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