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Unconventional translation of mammalian LINE-1 retrotransposons

Long Interspersed Element-1 (LINE-1 or L1) retrotransposons encode proteins required for their mobility (ORF1p and ORF2p), yet little is known about how L1 mRNA is translated. Here, we show that ORF2 translation generally initiates from the first in-frame methionine codon of ORF2, and that both ORF1...

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Detalhes bibliográficos
Main Authors: Alisch, Reid S., Garcia-Perez, Jose L., Muotri, Alysson R., Gage, Fred H., Moran, John V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356112/
https://ncbi.nlm.nih.gov/pubmed/16418485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1380406
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