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Catalytic Enantioselective Ynamide Additions to Isatins: Concise Access to Oxindole Alkaloids

The highly enantioselective addition of terminal ynamides to a variety of isatins, catalyzed by a bisoxazolidine copper complex under mild, base-free reaction conditions, is described. The reaction is broad in scope, scalable, applicable to unprotected isatins and provides efficient access to 3-hydr...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Moskowitz, Max, Wolf, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444906/
https://ncbi.nlm.nih.gov/pubmed/30695127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814074
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