Secretory Inositol Polyphosphate 4-Phosphatase Protects against Airway Inflammation and Remodeling

The asthma candidate gene inositol polyphosphate 4-phosphatase type I A (INPP4A) is a lipid phosphatase that negatively regulates the PI3K/Akt pathway. Destabilizing genetic variants of INPP4A increase the risk of asthma, and lung-specific INPP4A knockdown induces asthma-like features. INPP4A is kno...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Respir Cell Mol Biol
Prif Awduron: Khanna, Kritika, Chaudhuri, Rituparna, Aich, Jyotirmoi, Pattnaik, Bijay, Panda, Lipsa, Prakash, Y. S., Mabalirajan, Ulaganathan, Ghosh, Balaram, Agrawal, Anurag
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2019
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444634/
https://ncbi.nlm.nih.gov/pubmed/30335467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0353OC
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