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Secretory Inositol Polyphosphate 4-Phosphatase Protects against Airway Inflammation and Remodeling
The asthma candidate gene inositol polyphosphate 4-phosphatase type I A (INPP4A) is a lipid phosphatase that negatively regulates the PI3K/Akt pathway. Destabilizing genetic variants of INPP4A increase the risk of asthma, and lung-specific INPP4A knockdown induces asthma-like features. INPP4A is kno...
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| Pubblicato in: | Am J Respir Cell Mol Biol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Thoracic Society
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6444634/ https://ncbi.nlm.nih.gov/pubmed/30335467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0353OC |
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