Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the hypothesis that Vit-E may b...

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Autors principals: Mabalirajan, Ulaganathan, Aich, Jyotirmoi, Leishangthem, Geeta Devi, Sharma, Surendra Kumar, Dinda, Amit Kumar, Ghosh, Balaram
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2009
Matèries:
Innovative Methodologies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763843/
https://ncbi.nlm.nih.gov/pubmed/19628725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00459.2009
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