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An improved synthesis of adefovir and related analogues

An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium tert-butoxide and DMF, to achieve high conversions to the target. A systematic study...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Jones, David J, O’Leary, Eileen M, O’Sullivan, Timothy P
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6444443/
https://ncbi.nlm.nih.gov/pubmed/30992729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.77
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