Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure

Surfactant protein A (SP-A) plays critical roles in host defense, regulation of inflammation and surfactant metabolism in the lung. The human SP-A locus consists of two functional genes, SFTPA1 and SFTPA2 encoding surfactant proteins SP-A1 and SP-A2, respectively. Structural and functional differenc...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Guirong, Umstead, Todd M., Hu, Sanmei, Mikerov, Anatoly N., Phelps, David S., Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443908/
https://ncbi.nlm.nih.gov/pubmed/30972061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00561
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