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Bub1—the zombie protein that CRISPR cannot kill

The conserved Bub1 kinase was proposed to be non‐essential for the mitotic spindle assembly checkpoint based on recent findings that knocking‐out Bub1 by CRISPR/Cas9 did not impair checkpoint function in human cells. New studies now demonstrate that CRISPR/Cas9 Bub1 knockout cells still express low...

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Detalhes bibliográficos
Publicado no:EMBO J
Autor principal: Meraldi, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443206/
https://ncbi.nlm.nih.gov/pubmed/30850387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101912
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