11ß-Hydroxysteroid Dehydrogenase Type 2 Protects the Neonatal Cerebellum From Deleterious Effects of Glucocorticoids

11ß-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives. As 11ß-hydroxysteroid dehydrogenase type 2 is highly expressed in the developing brain, but not in the adult CNS, we hypothes...

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Udgivet i:Neuroscience
Main Authors: Holmes, M. C., Sangra, M., French, K. L., Whittle, I. R., Paterson, J., Mullins, J. J., Seckl, J. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443040/
https://ncbi.nlm.nih.gov/pubmed/16289840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2005.09.037
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