The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14

The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved myelofibrosis in a mouse model of JAK2-V617F-positive myeloproliferative neoplasms. We therefore tested the effectiveness of mirabegron, a β-3 sympatho...

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Publicado no:Haematologica
Main Authors: Drexler, Beatrice, Passweg, Jakob R., Tzankov, Alexandar, Bigler, Martin, Theocharides, Alexandre PA, Cantoni, Nathan, Keller, Peter, Stussi, Georg, Ruefer, Axel, Benz, Rudolf, Favre, Geneviève, Lundberg, Pontus, Nienhold, Ronny, Fuhrer, Andrea, Biaggi, Christine, Manz, Markus G., Bargetzi, Mario, Mendez-Ferrer, Simon, Skoda, Radek C.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442970/
https://ncbi.nlm.nih.gov/pubmed/30409796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.200014
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