Identification and Characterization of DNA Aptamers Specific for Phosphorylation Epitopes of Tau Protein

Tau proteins are proteins that stabilize micro-tubules, but their hyperphosphorylation can result in the formation of protein aggregates and, over time, neuro-degeneration. This phenomenon, termed tauopathy, is pathologically involved in several neurodegenerative disorders. DNA aptamers are single-s...

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Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Teng, I-Ting, Li, Xiaowei, Yadikar, Hamad Ahmad, Yang, Zhihui, Li, Long, Lyu, Yifan, Pan, Xiaoshu, Wang, Kevin K., Tan, Weihong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442731/
https://ncbi.nlm.nih.gov/pubmed/30277395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08645
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