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Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation

Gd-based MRI contrast agents (GBCAs) have come under intense regulatory scrutiny due to concerns of Gd retention and delayed toxicity. Three GBCAs comprising acyclic Gd chelates, the class of GBCA most prone to Gd release, are no longer marketed in Europe. Of particular concern are the acyclic chela...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Wang, Junfeng, Wang, Huan, Ramsay, Ian A., Erstad, Derek J., Fuchs, Bryan C., Tanabe, Kenneth K., Caravan, Peter, Gale, Eric M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442678/
https://ncbi.nlm.nih.gov/pubmed/30204438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00964
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