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Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation

Gd-based MRI contrast agents (GBCAs) have come under intense regulatory scrutiny due to concerns of Gd retention and delayed toxicity. Three GBCAs comprising acyclic Gd chelates, the class of GBCA most prone to Gd release, are no longer marketed in Europe. Of particular concern are the acyclic chela...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Wang, Junfeng, Wang, Huan, Ramsay, Ian A., Erstad, Derek J., Fuchs, Bryan C., Tanabe, Kenneth K., Caravan, Peter, Gale, Eric M.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442678/
https://ncbi.nlm.nih.gov/pubmed/30204438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00964
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