Epigenomic promoter alterations predict for benefit from immune checkpoint inhibition in metastatic gastric cancer

BACKGROUND: Utilization of alternative transcription start sites through alterations in epigenetic promoter regions causes reduced expression of immunogenic N-terminal peptides, which may facilitate immune evasion in early gastric cancer. We hypothesized that tumors with high alternate promoter util...

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Enregistré dans:
Détails bibliographiques
Publié dans:Ann Oncol
Auteurs principaux: Sundar, R, Huang, K K, Qamra, A, Kim, K -M, Kim, S T, Kang, W K, Tan, A L K, Lee, J, Tan, P
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442650/
https://ncbi.nlm.nih.gov/pubmed/30624548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdy550
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