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Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in which we have specifically inactivated both insulin receptors (IRs) and IGF-1 receptors (IGF1Rs) in the hippocampus (Hi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Soto, Marion, Cai, Weikang, Konishi, Masahiro, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442573/
https://ncbi.nlm.nih.gov/pubmed/30765523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817391116
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