DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development

BACKGROUND: Cytosine methylation of regulatory regions, such as promoters and enhancers, plays a key role in regulating gene expression, however, its role in kidney development has not been analyzed. METHODS: To identify functionally important epigenome-modifying enzymes and genome regions where met...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Li, Szu-Yuan, Park, Jihwan, Guan, Yuting, Chung, Kiwung, Shrestha, Rojesh, Palmer, Matthew B., Susztak, Katalin
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2019
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442333/
https://ncbi.nlm.nih.gov/pubmed/30850438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070687
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