Rationale for Using Irreversible Epidermal Growth Factor Receptor Inhibitors in Combination with Phosphatidylinositol 3-Kinase Inhibitors for Advanced Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) is a common and debilitating form of cancer characterized by poor patient outcomes and low survival rates. In HNSCC, genetic aberrations in phosphatidylinositol 3-kinase (PI3K) and epidermal growth factor receptor (EGFR) pathway genes are common, and sma...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Michmerhuizen, Nicole L., Leonard, Elizabeth, Matovina, Chloe, Harris, Micah, Herbst, Gabrielle, Kulkarni, Aditi, Zhai, Jingyi, Jiang, Hui, Carey, Thomas E., Brenner, J. Chad
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2019
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442321/
https://ncbi.nlm.nih.gov/pubmed/30858165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.115162
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