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Differential compensation mechanisms define resistance to PI3K inhibitors in PIK3CA amplified HNSCC
OBJECTIVE: Recent sequencing studies of head and neck squamous cell carcinomas (HNSCCs) have identified the phosphatidylinositol 3-kinase (PI3K) pathway as the most frequently mutated, oncogenic pathway in this cancer type. Despite the frequency of activating genomic alterations in PIK3CA (the gene...
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| Veröffentlicht in: | Otorhinolaryngol Head Neck Surg |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5167357/ https://ncbi.nlm.nih.gov/pubmed/28004037 |
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