Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

The base excision repair (BER) pathway is an important DNA repair pathway and is essential for immune responses. In fact, it regulates both the antigen-stimulated somatic hypermutation (SHM) process and plays a central function in the process of class switch recombination (CSR). For both processes,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Frossi, Barbara, Antoniali, Giulia, Yu, Kefei, Akhtar, Nahid, Kaplan, Mark H., Kelley, Mark R., Tell, Gianluca, Pucillo, Carlo E. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442068/
https://ncbi.nlm.nih.gov/pubmed/30705092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006601
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