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Pancreatic β-cells detoxify H(2)O(2) through the peroxiredoxin/thioredoxin antioxidant system
Oxidative stress is thought to promote pancreatic β-cell dysfunction and contribute to both type 1 and type 2 diabetes. Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, are mediators of oxidative stress that arise largely from electron leakage during oxidative phosphorylation...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442057/ https://ncbi.nlm.nih.gov/pubmed/30659092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006219 |
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