8-Oxo-guanine DNA damage induces transcription errors by escaping two distinct fidelity control checkpoints of RNA polymerase II

RNA polymerase II (Pol II) has an intrinsic fidelity control mechanism to maintain faithful genetic information transfer during transcription. 8-Oxo-guanine (8OG), a commonly occurring damaged guanine base, promotes misincorporation of adenine into the RNA strand. Recent structural work has shown th...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Konovalov, Kirill A., Pardo-Avila, Fátima, Tse, Carmen Ka Man, Oh, Juntaek, Wang, Dong, Huang, Xuhui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442046/
https://ncbi.nlm.nih.gov/pubmed/30718278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007333
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