High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1

Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysine 14 (H3K14ac), it is not known whether other BDs coll...

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Detaylı Bibliyografya
Yayımlandı:Mol Oncol
Asıl Yazarlar: Liao, Lili, Alicea‐Velázquez, Nilda L., Langbein, Lauren, Niu, Xiaohua, Cai, Weijia, Cho, Eun‐Ah, Zhang, Meiling, Greer, Celeste B., Yan, Qin, Cosgrove, Michael S., Yang, Haifeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441893/
https://ncbi.nlm.nih.gov/pubmed/30585695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12434
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