Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells

BACKGROUND: The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC). METHODS: Cortactin and phosphorylated co...

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Publicat a:Cancer Cell Int
Autors principals: Stock, Katharina, Borrink, Rebekka, Mikesch, Jan-Henrik, Hansmeier, Anna, Rehkämper, Jan, Trautmann, Marcel, Wardelmann, Eva, Hartmann, Wolfgang, Sperveslage, Jan, Steinestel, Konrad
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441202/
https://ncbi.nlm.nih.gov/pubmed/30976201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0798-x
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