Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells

BACKGROUND: The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC). METHODS: Cortactin and phosphorylated co...

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Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Stock, Katharina, Borrink, Rebekka, Mikesch, Jan-Henrik, Hansmeier, Anna, Rehkämper, Jan, Trautmann, Marcel, Wardelmann, Eva, Hartmann, Wolfgang, Sperveslage, Jan, Steinestel, Konrad
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441202/
https://ncbi.nlm.nih.gov/pubmed/30976201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0798-x
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