Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells

BACKGROUND: The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pancreatic ductal adenocarcinoma (PDAC). METHODS: Cortactin and phosphorylated co...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Stock, Katharina, Borrink, Rebekka, Mikesch, Jan-Henrik, Hansmeier, Anna, Rehkämper, Jan, Trautmann, Marcel, Wardelmann, Eva, Hartmann, Wolfgang, Sperveslage, Jan, Steinestel, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441202/
https://ncbi.nlm.nih.gov/pubmed/30976201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0798-x
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