Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma

Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric EWSR1‐ETS fusion oncogenes, most often EWSR1‐FLI1 (E/F). E/F expression leads to dysregulation of focal adhesions (FAs) enhancing the migratory cap...

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Vydáno v:Mol Oncol
Hlavní autoři: Steinestel, Konrad, Trautmann, Marcel, Jansen, Esther‐Pia, Dirksen, Uta, Rehkämper, Jan, Mikesch, Jan‐Henrik, Gerke, Julia S., Orth, Martin F., Sannino, Giuseppina, Arteaga, Maria‐Francisca, Rossig, Claudia, Wardelmann, Eva, Grünewald, Thomas G. P., Hartmann, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6998388/
https://ncbi.nlm.nih.gov/pubmed/31811703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12610
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