Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans

The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to...

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I publikationen:Sci Rep
Huvudupphovsmän: Chang, Anne-Marie, Duffy, Jeanne F., Buxton, Orfeu M., Lane, Jacqueline M., Aeschbach, Daniel, Anderson, Clare, Bjonnes, Andrew C., Cain, Sean W., Cohen, Daniel A., Frayling, Timothy M., Gooley, Joshua J., Jones, Samuel E., Klerman, Elizabeth B., Lockley, Steven W., Munch, Mirjam, Rajaratnam, Shantha M. W., Rueger, Melanie, Rutter, Martin K., Santhi, Nayantara, Scheuermaier, Karine, Van Reen, Eliza, Weedon, Michael N., Czeisler, Charles A., Scheer, Frank A. J. L., Saxena, Richa
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440993/
https://ncbi.nlm.nih.gov/pubmed/30926824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41712-1
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