Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans

The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to...

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Publicado no:Sci Rep
Main Authors: Chang, Anne-Marie, Duffy, Jeanne F., Buxton, Orfeu M., Lane, Jacqueline M., Aeschbach, Daniel, Anderson, Clare, Bjonnes, Andrew C., Cain, Sean W., Cohen, Daniel A., Frayling, Timothy M., Gooley, Joshua J., Jones, Samuel E., Klerman, Elizabeth B., Lockley, Steven W., Munch, Mirjam, Rajaratnam, Shantha M. W., Rueger, Melanie, Rutter, Martin K., Santhi, Nayantara, Scheuermaier, Karine, Van Reen, Eliza, Weedon, Michael N., Czeisler, Charles A., Scheer, Frank A. J. L., Saxena, Richa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440993/
https://ncbi.nlm.nih.gov/pubmed/30926824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41712-1
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