Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology

The risk of type 2 diabetes (T2D) is increased by abnormalities in sleep quantity and quality, circadian alignment, and melatonin regulation. A common genetic variant in a receptor for the circadian-regulated hormone melatonin (MTNR1B) is associated with increased fasting blood glucose and risk of T...

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Veröffentlicht in:Diabetes
Hauptverfasser: Lane, Jacqueline M., Chang, Anne-Marie, Bjonnes, Andrew C., Aeschbach, Daniel, Anderson, Clare, Cade, Brian E., Cain, Sean W., Czeisler, Charles A., Gharib, Sina A., Gooley, Joshua J., Gottlieb, Daniel J., Grant, Struan F.A., Klerman, Elizabeth B., Lauderdale, Diane S., Lockley, Steven W., Munch, Miriam, Patel, Sanjay, Punjabi, Naresh M., Rajaratnam, Shanthakumar M.W., Rueger, Melanie, St. Hilaire, Melissa A., Santhi, Nayantara, Scheuermaier, Karin, Van Reen, Eliza, Zee, Phyllis C., Shea, Steven A., Duffy, Jeanne F., Buxton, Orfeu M., Redline, Susan, Scheer, Frank A.J.L., Saxena, Richa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2016
Schlagworte:
Genetics/Genomes/Proteomics/Metabolomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878414/
https://ncbi.nlm.nih.gov/pubmed/26868293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0999
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