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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
For preclinical and clinical assessment of therapeutically relevant unbound, free, brain concentrations, the pharmacokinetic parameter fraction of unbound drug in brain (f(u,brain)) is commonly used to compensate total drug concentrations for nonspecific brain tissue binding (BTB). As, homogenous BT...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440985/ https://ncbi.nlm.nih.gov/pubmed/30926941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41828-4 |
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