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Improved measurement of drug exposure in the brain using drug-specific correction for residual blood
A major challenge associated with the determination of the unbound brain-to-plasma concentration ratio of a drug (K(p,uu,brain)), is the error associated with correction for the drug in various vascular spaces of the brain, i.e., in residual blood. The apparent brain vascular spaces of plasma water...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949109/ https://ncbi.nlm.nih.gov/pubmed/19756019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.200 |
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