Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with hig...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Basnet, Harihar, Tian, Lin, Ganesh, Karuna, Huang, Yun-Han, Macalinao, Danilo G, Brogi, Edi, Finley, Lydia WS, Massagué, Joan
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440742/
https://ncbi.nlm.nih.gov/pubmed/30912515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43627
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