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Cell-autonomous clock of astrocytes drives circadian behavior in mammals

Circadian (~24h) rhythms depend on intra-cellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks achieve multi-cellular integration and thereby direct daily rhythms of behavior in animals is largely obscure. The suprachiasmatic nucleus (SCN) is th...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Brancaccio, Marco, Edwards, Mathew D., Patton, Andrew P., Smyllie, Nicola J., Chesham, Johanna E, Maywood, Elizabeth S., Hastings, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440650/
https://ncbi.nlm.nih.gov/pubmed/30630934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat4104
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