Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling

Constitutive activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common oncogenic event in certain types of human cancer and is associated with poor patient survival. Small molecule signaling inhibitors have improved the clinical outcomes of patients with various cancer types...

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Publicat a:Biomed Rep
Autors principals: Cimino, Patrick J., Huang, Lan, Du, Lihua, Wu, Yanping, Bishop, Jamie, Dalsing-Hernandez, Jessica, Kotlarczyk, Kari, Gonzales, Paul, Carew, Jennifer, Nawrocki, Steffan, Jordan, Mary Ann, Wilson, Leslie, Lloyd, G. Kenneth, Wirsching, Hans-Georg
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2019
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439430/
https://ncbi.nlm.nih.gov/pubmed/30972217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2019.1196
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