Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

GWAS have identified 108 schizophrenia risk loci, but risk mechanisms for individual loci are largely unknown. Using developmental, genetic, and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for...

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Publicado en:Nat Neurosci
Autores principales: Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438700/
https://ncbi.nlm.nih.gov/pubmed/30050107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0197-y
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