Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Fanconi anemia (FA) is a rare inherited syndrome characterized by progressive bone marrow failure (BMF), abnormal skin pigmentation, short stature, and increased cancer risk. BMF in FA is multifactorial and largely results from the death of hematopoietic stem cells due to genomic instability. Also,...

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Vydáno v:Front Immunol
Hlavní autoři: Shabrish, Snehal, Kelkar, Madhura, Chavan, Niranjan, Desai, Mukesh, Bargir, Umair, Gupta, Maya, Mehta, Priti, Chichra, Akanksha, S, Chandrakala, Taur, Prasad, Saxena, Vinay, Vundinti, Babu Rao, Madkaikar, Manisha
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438155/
https://ncbi.nlm.nih.gov/pubmed/30949167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00490
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