Natural Killer Cell Degranulation Defect: A Cause for Impaired NK-Cell Cytotoxicity and Hyperinflammation in Fanconi Anemia Patients

Fanconi anemia (FA) is a rare inherited syndrome characterized by progressive bone marrow failure (BMF), abnormal skin pigmentation, short stature, and increased cancer risk. BMF in FA is multifactorial and largely results from the death of hematopoietic stem cells due to genomic instability. Also,...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Shabrish, Snehal, Kelkar, Madhura, Chavan, Niranjan, Desai, Mukesh, Bargir, Umair, Gupta, Maya, Mehta, Priti, Chichra, Akanksha, S, Chandrakala, Taur, Prasad, Saxena, Vinay, Vundinti, Babu Rao, Madkaikar, Manisha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438155/
https://ncbi.nlm.nih.gov/pubmed/30949167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00490
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